A study of the effectiveness of rifaprim in chronic prostatitis caused mainly by Staphylococcus aureus.

Abstract

Rifampicin plus trimethoprim (rifaprim) was used to treat 20 patients with chronic prostatitis in exacerbation: 11 received 2 tablets at bedtime for 15 days followed by 1 tablet at bedtime for another 105 days, and 9 received 1 tablet in the morning and 2 tablets at bedtime for 15 days, then 2 tablets at bedtime for 15 days followed by 1 tablet at bedtime for another 90 days. All patients had an enlarged tender prostate and all but 2 were symptomatic. In 10 patients previous treatment, including co-trimoxazole in 5, had failed. Cultures of the expressed prostatic secretions yielded Staphylococcus aureus in 17 patients and gram-negative micro-organisms in 3. At the end of treatment 6 of 11 patients given the lower dosage were cured clinically and bacteriologically compared to 8 of 9 given the higher dosage. After 2 to 3 years of following 5 of 9 patients in the first group and all 7 in the second group had not suffered relapse. From our study it is evident that rifaprim is a potent drug in the treatment of chronic prostatitis caused mainly by Staphylococcus aureus. A promptness of therapeutic response and the rate of cure at the end of treatment as well as after at least 2 years of followup favor the higher drug dosage.

• Authors: H Giamarellou, J Kosmidis, M Leonidas, M Papadakis, G K Daikos
• Journal: The Journal of urology (J Urol) Vol. 128 Issue 2 Pg. 321-4 (Aug 1982) ISSN: 0022-5347 [Print] United States
• PMID: 7109100 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Rifaprim
• Trimethoprim
• Rifampin

Topics

• Adult
• Chronic Disease
• Drug Combinations (administration & dosage)
• Humans
• Male
• Middle Aged
• Prostatitis (drug therapy, microbiology)
• Rifampin (administration & dosage)
• Staphylococcal Infections (drug therapy, microbiology)
• Trimethoprim (administration & dosage)