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Ionic mechanisms of the rapid (nicotinic) phase of acetylcholine response in identified Planobarius corneus neurones.

Abstract
Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes show that in LPed-2 neurone two kinds of cholinoreceptors are involved in the rapid phase of ACh response one of which induces chloride conductance and the other, sodium conductance. The Cl-dependent component can be separated from the cationic one by C-6 whereas the cationic component can be separated from the Cl--dependent one by furosemide. Cl- conductance can be induced selectively by D-6. In the LPed-3 neurone only Cl- conductance increases during rapid phase of ACh response. The reversal potential of Cl--dependent responses was found to be more negative than the resting potential in experiments made with K2SO4-filled microelectrodes but less negative than the resting potential in the case of KCl-filled microelectrodes. This difference seems to be due to the artificial increase of intracellular chloride concentration.
AuthorsA N Katchman, E V Zeimal
JournalBrain research (Brain Res) Vol. 241 Issue 1 Pg. 95-103 (Jun 03 1982) ISSN: 0006-8993 [Print] Netherlands
PMID7104710 (Publication Type: Journal Article)
Chemical References
  • Chlorides
  • Receptors, Cholinergic
  • Receptors, Nicotinic
  • subecholine
  • Furosemide
  • Sodium
  • Choline
  • Acetylcholine
Topics
  • Acetylcholine (pharmacology)
  • Animals
  • Chlorides (pharmacology)
  • Choline (analogs & derivatives, pharmacology)
  • Electric Conductivity
  • Furosemide (pharmacology)
  • Kinetics
  • Membrane Potentials (drug effects)
  • Mollusca (physiology)
  • Neurons (physiology)
  • Receptors, Cholinergic (physiology)
  • Receptors, Nicotinic (drug effects, physiology)
  • Sodium (pharmacology)

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