Plasma alpha- and beta-mannosidase activities in caprine beta-mannosidosis.

Abstract

Plasma alpha- and beta-mannosidase activities were measured in goats with beta-mannosidosis, a recently discovered, inherited deficiency of the glycohydrolase beta-D-mannosidase. Plasma beta-mannosidase activity in the affected animals was zero at 1 and 4 weeks after they were born. Enzyme values of age-matched, unaffected goats were between 66 and 222 nmol/hr/ml of plasma, alpha-Mannosidase activities were similar in both affected and unaffected animals. This investigation indicates that deficiency of plasma beta-mannosidases activity may be diagnostic of beta-mannosidosis.

• Authors: K Cavanagh, R W Dunstan, M Z Jones
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 43 Issue 6 Pg. 1058-9 (Jun 1982) ISSN: 0002-9645 [Print] United States
• PMID: 7103175 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Mannosidases
• alpha-Mannosidase
• beta-Mannosidase

Topics

• Animals
• Animals, Newborn (metabolism)
• Female
• Goats (metabolism)
• Male
• Mannosidases (blood, metabolism)
• Metabolism, Inborn Errors (blood, enzymology, veterinary)
• Pedigree
• alpha-Mannosidase
• beta-Mannosidase