[Search for a new rinsing solution for the local lysis of calcium-containing urinary calculi].

Abstract

Due to improved rinsing techniques local chemolitholysis is again becoming more important. Good result good results in the local chemolysis of phosphate calculi (calculi caused by remains of Struvit) with Renacidin and other rinsing solutions (Fam, Rossier, Gittes, Jacobs, Smith, Royle, Nemoy, Stamey) have led to a revival chemolitholysis (Alken) in the last 4--5 years, however only in the case of phosphate calculi, which account for 60--80%, cannot be dissolved by Renacidin, as is explicitly pointed out by the manufacturer. The experiments carried out by the group headed by Kallistratos and Timmermann in the 60's using rinsing solutions based on EDTA were discontinued, probably because of physiological reservations concerning the chemicals used and the long duration of treatment at physiologically tolerable concentrations and pH values. In order to extend the range of rinsing solutions to be tested, we tested new substances, including some which complex not only the anion (oxalate) but also the cation (Ca). Alternating treatment with oxalate binding and Ca binding rinsing solutions has been found to give particularly good results.

• Authors: P Leskovar, M Hropot, E Wellnhofer
• Journal: Zeitschrift fur Urologie und Nephrologie (Z Urol Nephrol) Vol. 75 Issue 4 Pg. 245-52 (Apr 1982) ISSN: 0044-3611 [Print] Germany
• Vernacular Title: Suche nach neuen Spüllösungen für die lokale Lyse von Ca-haltigen Harnsteinen.
• PMID: 7102135 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chelating Agents
• Calcium Oxalate

Topics

• Calcium Oxalate (metabolism)
• Chelating Agents (therapeutic use)
• Humans
• Prognosis
• Therapeutic Irrigation
• Urinary Calculi (drug therapy, metabolism)