The use of Erlangen diamidine 98/202 in relapsing Trypanosoma brucei infections in mice.

Abstract

Mice infected with T. brucei GVR 23/1 or T. brucei GVR 35/1 for 21 days were treated with the Erlangen diamidine 98/202 (6-amidino-2-[4' amidino-phenyl] thionaphthene-dilacate) at either 5 mg/kg or 35 mg/kg. At both these dose levels the parasites were initially cleared from the circulation although the infections eventually relapsed due to reinvasion from the central nervous system. If the 98/202 therapy is followed by treatment with 5-nitroimidazole only a small number of mice are permanently cured. Adverse reactions, especially at the 35 mg/kg dose level, were noted in one experiment. The Erlangen diamidine given to infected mice three days after infection was able to permanently cure both Trypanosoma brucei stabilates.

• Authors: F W Jennings, G D Gray, G M Urquhart
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 76 Issue 2 Pg. 204-7 ( 1982) ISSN: 0035-9203 [Print] England
• PMID: 7101405 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amidines
• Trypanocidal Agents
• 98-202

Topics

• Amidines (therapeutic use)
• Animals
• Brain (parasitology)
• Cattle
• Mice
• Mice, Inbred Strains
• Recurrence
• Trypanocidal Agents (therapeutic use)
• Trypanosoma brucei brucei
• Trypanosomiasis, African (drug therapy, parasitology)