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An unusual case of ocular involvement in primary systemic nonfamilial amyloidosis.

Abstract
A case of primary amyloidosis with vitreous involvement was diagnosed by study of a specimen obtained by pars plana vitrectomy. Vitreous opacities had been interpreted clinically as a vitreous hemorrhage. Medical evaluation after study of the vitreous specimen failed to demonstrate evidence of amyloidosis, although postmortem examination 19 months later established the systemic diagnosis of nonfamilial systemic primary amyloidosis. Both eyes were obtained postmortem. Amyloid involvement of the vitreous, retina, and choroid was found. There was also amyloid deposition in the trabecular meshwork, although the intraocular pressure was normal. Amyloid was deposited along the anterior, pupillary, and posterior surfaces of the iris. The histochemistry, ultrastructure, and treatment of this condition are discussed.
AuthorsM F Schwartz, W R Green, R G Michels, M C Kincaid, J Fogle
JournalOphthalmology (Ophthalmology) Vol. 89 Issue 4 Pg. 394-401 (Apr 1982) ISSN: 0161-6420 [Print] United States
PMID7099557 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amyloid
Topics
  • Amyloid
  • Amyloidosis (complications)
  • Choroid (pathology)
  • Eye Diseases (complications, pathology)
  • Female
  • Humans
  • Iris (pathology, ultrastructure)
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Retina (pathology)
  • Vitreous Body (pathology, surgery)

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