Experimental protein malnutrition decreases calcium-binding protein in rat intestinal mucosa.

Abstract

Calcium-binding activity was measured in duodenal mucosal homogenates of rats 50 days after weaning onto a protein-deficient diet providing 3-4 g of protein per kilogram of body weight per day compared to control animals, who were fed an isocaloric diet providing 9-12 g of protein per kilogram of body weight per day. Calcium-binding activity was decreased (44% of control) further than can be explained by the decrease in intestinal mucosal weight (70% of control) or supernatant protein content (80% of control). The results suggest that the decrease in calcium-binding activity reflects decreased synthesis of the vitamin D-dependent calcium-binding protein (CaBP) as an adaptive response to the stunted growth associated with protein malnutrition.

• Authors: W A Gleason, G L Lankford, D C Herbert
• Journal: The Journal of nutrition (J Nutr) Vol. 112 Issue 8 Pg. 1609-13 (Aug 1982) ISSN: 0022-3166 [Print] United States
• PMID: 7097368 (Publication Type: Journal Article)

Chemical References

• Calcium-Binding Proteins
• Dietary Proteins
• S100 Calcium Binding Protein G
• Calcium

Topics

• Animals
• Body Weight
• Calcium (metabolism)
• Calcium-Binding Proteins (metabolism)
• Dietary Proteins (administration & dosage)
• Duodenum (metabolism)
• Intestinal Mucosa (metabolism, pathology)
• Male
• Organ Size
• Protein Deficiency (metabolism)
• Rats
• Rats, Inbred Strains
• S100 Calcium Binding Protein G (metabolism)