Hepatic osteodystrophy.

Abstract

Hepatic osteodystrophy consists of three types: osteomalacia, osteoporosis, and periosteal reaction with new bone formation. Secondary hyperparathyroidism is very rare, if it occurs at all. The cause of osteomalacia appears to be vitamin D deficiency due to a lack of vitamin D substrate. In the presence of adequate substrates, 25-OHD and dihydroxy vitamin D metabolites are formed. The vitamin D deficiency results in osteomalacia and malabsorption of calcium and phosphorus. The osteomalacia can be treated successfully with vitamin D supplements. In some patients calcium, phosphorus, and magnesium supplements may be required. The aetiology and treatment of the osteoporosis and the periosteal reactions remain obscure.

• Authors: R G Long, M R Wills
• Journal: British journal of hospital medicine (Br J Hosp Med) Vol. 20 Issue 3 Pg. 312-21 (Sep 1978) ISSN: 0007-1064 [Print] England
• PMID: 708974 (Publication Type: Journal Article)

Chemical References

• Parathyroid Hormone
• Vitamin D
• Phosphorus
• Calcium

Topics

• Bone and Bones (pathology)
• Calcium (metabolism)
• Celiac Disease (complications, metabolism)
• Cholestasis (complications, metabolism, pathology)
• Hepatitis, Alcoholic (metabolism, pathology)
• Humans
• Osteomalacia (metabolism, pathology)
• Osteoporosis (metabolism, pathology)
• Parathyroid Hormone (blood)
• Phosphorus (metabolism)
• Vitamin D (metabolism, therapeutic use)
• Vitamin D Deficiency (metabolism)