Cochlear cytoarchitecture and ribostamycin ototoxicity.

Abstract

Ribostamycin ototoxicity was tested in a group of 28 albino guinea-pigs of both sexes, body-weight about 250-450 g with auricular Prayer's reflex present. The mounting of the cochlea on a metal support and the scanning electron microscope observations are described, The cochleacytogram of the group treated daily with 200 mg/kg ten days consecutively is comparable to that of the non-treated group.

• Authors: G B Catalano, A Serra
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 4 Issue 1 Pg. 41-53 ( 1982) ISSN: 0250-0868 [Print] Switzerland
• PMID: 7084999 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Ribostamycin

Topics

• Animals
• Anti-Bacterial Agents (toxicity)
• Cochlea (drug effects, ultrastructure)
• Female
• Guinea Pigs
• Hair Cells, Auditory (ultrastructure)
• Hair Cells, Auditory, Inner (ultrastructure)
• Labyrinth Supporting Cells (ultrastructure)
• Male
• Microscopy, Electron, Scanning
• Organ of Corti (ultrastructure)
• Ribostamycin (toxicity)