Abstract |
Forty-one patients with inflammatory or degenerative arthritis and a history of gastric disturbance on other non- steroid anti-inflammatory drugs, or of peptic ulceration were treated with fenbufen 600-1200 mg dialy, and followed up for 3-17 months in an open study. Twelve patients withdrew because of lack of effect of the drug on the arthritic symptoms. Four patients withdrew because of non-gastrointestinal side effects. Three patients withdrew because of continuing dyspepsia. Twenty-two patients continued on fenbufen without dyspepsia or evidence of gastro-intestinal bleeding for 3-17 months (mean 8.3 months). These results suggest that fenbufen can be tolerated by patients with a history of gastro-intestinal disturbance on other NSAIDs, and that a larger controlled study would be warranted.
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Authors | E W Paice, A J Tookman, A G White |
Journal | European journal of rheumatology and inflammation
(Eur J Rheumatol Inflamm)
Vol. 5
Issue 3
Pg. 301-3
( 1982)
ISSN: 0140-1610 [Print] England |
PMID | 7084291
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Phenylbutyrates
- Propionates
- fenbufen
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Topics |
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, adverse effects)
- Arthritis, Rheumatoid
(drug therapy)
- Drug Tolerance
- Female
- Humans
- Peptic Ulcer Hemorrhage
(chemically induced, drug therapy)
- Phenylbutyrates
- Propionates
(administration & dosage, adverse effects)
- Stomach
(drug effects)
- Stomach Ulcer
(complications)
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