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Fenbufen in patients with gastric intolerance.

Abstract
Forty-one patients with inflammatory or degenerative arthritis and a history of gastric disturbance on other non-steroid anti-inflammatory drugs, or of peptic ulceration were treated with fenbufen 600-1200 mg dialy, and followed up for 3-17 months in an open study. Twelve patients withdrew because of lack of effect of the drug on the arthritic symptoms. Four patients withdrew because of non-gastrointestinal side effects. Three patients withdrew because of continuing dyspepsia. Twenty-two patients continued on fenbufen without dyspepsia or evidence of gastro-intestinal bleeding for 3-17 months (mean 8.3 months). These results suggest that fenbufen can be tolerated by patients with a history of gastro-intestinal disturbance on other NSAIDs, and that a larger controlled study would be warranted.
AuthorsE W Paice, A J Tookman, A G White
JournalEuropean journal of rheumatology and inflammation (Eur J Rheumatol Inflamm) Vol. 5 Issue 3 Pg. 301-3 ( 1982) ISSN: 0140-1610 [Print] England
PMID7084291 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Phenylbutyrates
  • Propionates
  • fenbufen
Topics
  • Adult
  • Aged
  • Anti-Inflammatory Agents (administration & dosage, adverse effects)
  • Arthritis, Rheumatoid (drug therapy)
  • Drug Tolerance
  • Female
  • Humans
  • Peptic Ulcer Hemorrhage (chemically induced, drug therapy)
  • Phenylbutyrates
  • Propionates (administration & dosage, adverse effects)
  • Stomach (drug effects)
  • Stomach Ulcer (complications)

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