Abstract |
A specific, sensitive, rapid, and reproducible method for iprindole in human plasma was developed using gas chromatography with trimipramine as internal standard. The sensitivity of the method is of 5 ng ml-1 and a linearity was obtained for concentrations ranging from 12.5 ng ml-1 to 100 ng ml-1 with a regression coefficient of 0.9872. The plasma levels of iprindole were determined in five healthy volunteers following the administration of a single oral dose of 60 mg and in four patients admitted for endogenous depression after a 3-week administration of 90 mg d-1. Following a single oral dose to healthy volunteers, the maximum concentrations occurred between 2 and 4 h after administration of the drug and the mean half-life value was 52.5 h. In patients the steady-state concentrations of iprindole ranged between 18 and 77 ng ml-1.
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Authors | G Caillé, C de Montigny, J G Besner |
Journal | Biopharmaceutics & drug disposition
(Biopharm Drug Dispos)
1982 Jan-Mar
Vol. 3
Issue 1
Pg. 11-7
ISSN: 0142-2782 [Print] England |
PMID | 7082775
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Chromatography, Gas
(methods)
- Female
- Humans
- Indoles
(blood)
- Iprindole
(blood)
- Kinetics
- Male
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