Use of diuretics in treatment of hypertension secondary to renal disease.

Abstract

Eleven patients with hypertension secondary to renal disease were treated with hydrochlorothiazide or furosemide plus other drugs to normalize blood pressure. Creatinine clearance fell during the initial treatment period, but then either remained constant or rose toward pretreatment levels in spite of continued therapy. Plasma renin activity was low-normal to subnormal in eight of the 11 patients prior to therapy and did not rise significantly with therapy. Aldosterone excretion was within the normal range prior to treatment and remained normal or increased moderately with treatment. This study demonstrates that diuretics effectively reduce blood pressure in patients with hypertension secondary to renal disease without producing severe volume depletion or clinically significant reduction in renal function. The low renin levels are consistent with other evidence that hypertension in these patients is related to salt and water retention.

• Authors: N Bank, P D Lief, O Piczon
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 138 Issue 10 Pg. 1524-9 (Oct 1978) ISSN: 0003-9926 [Print] United States
• PMID: 708175 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Hydrochlorothiazide
• Uric Acid
• Aldosterone
• Furosemide
• Sodium
• Creatinine
• Renin
• Potassium

Topics

• Adult
• Aldosterone (urine)
• Antihypertensive Agents (therapeutic use)
• Creatinine (blood)
• Female
• Furosemide (therapeutic use)
• Humans
• Hydrochlorothiazide (therapeutic use)
• Hypertension (drug therapy, etiology)
• Kidney Failure, Chronic (complications)
• Male
• Middle Aged
• Potassium (blood)
• Renin (blood)
• Sodium (urine)
• Uric Acid (blood)