Urinary acidic glycosaminoglycans in Werner's syndrome.

Abstract

The composition of urinary acidic glycosaminoglycans (AGAG) in 4 patients with Werner's syndrome was determined by an enzymatic assay system using chondroitinases and hyaluronidase. In Werner's syndrome, the amount of hyaluronic acid and heparan sulfates in the total AGAG increases. A compositional change in the chondroitin sulfate isomers occurs. The change of urinary AGAG in Werner's syndrome appears to reflect age-related changes.

• Authors: K Murata
• Journal: Experientia (Experientia) Vol. 38 Issue 3 Pg. 313-4 (Mar 15 1982) ISSN: 0014-4754 [Print] Switzerland
• PMID: 7075723 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycosaminoglycans
• Hyaluronoglucosaminidase
• Chondroitinases and Chondroitin Lyases

Topics

• Adult
• Chondroitinases and Chondroitin Lyases
• Female
• Glycosaminoglycans (urine)
• Humans
• Hyaluronoglucosaminidase
• Male
• Middle Aged
• Werner Syndrome (urine)