Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.

Abstract

Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), drugs which elicit the behavioral serotonin syndrome. Both drugs caused a slow depolarization, increased input resistance, and increased excitability of facial motoneurons. These changes are identical to those caused by direct microiontophoretic application of serotonin to these neurons, and probably underlie some of the components of the behavioral serotonin syndrome.

• Authors: C P Vandermaelen, G K Aghajanian
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 78 Issue 2 Pg. 233-6 (Feb 26 1982) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7075673 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Methoxydimethyltryptamines
• Serotonin
• p-Chloroamphetamine

Topics

• Animals
• Behavior, Animal (drug effects)
• Facial Nerve (drug effects)
• Male
• Membrane Potentials (drug effects)
• Methoxydimethyltryptamines (pharmacology)
• Motor Neurons (drug effects)
• Rats
• Serotonin (physiology)
• p-Chloroamphetamine (pharmacology)