Comparison of ruminant anthelmintics, using multiple dose administration.

Abstract

Eleven ruminant anthelmintics were administered to lambs over a 30-day period, using medicated feeds or multiple oral doses. Fenbendazole and its sulfinyl analog, oxfendazole, were effective (greater than 90%) in the control of clinical parasitism at feeding levels of 5 mg/kg of feed. Parbendazole and albendazole were effective at daily oral dose levels of 1 mg/kg of body weight and at feeding dose levels of 10 mg/kg of feed, respectively. Levamisole, mebendazole, and oxibendazole were ineffective in controlling intense natural parasitic infections of sheep at daily oral dose levels equal to or less than 1 mg/kg of body weight and/or a feeding level equal to or less than 10 mg/kg of feed.

• Authors: D K Hass, E L Holloway, L J Brown
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 43 Issue 3 Pg. 534-7 (Mar 1982) ISSN: 0002-9645 [Print] United States
• PMID: 7073071 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Benzimidazoles
• Carbamates
• Fenbendazole
• oxfendazole

Topics

• Animals
• Anthelmintics (administration & dosage, therapeutic use)
• Benzimidazoles (administration & dosage, therapeutic use)
• Carbamates (administration & dosage, therapeutic use)
• Drug Resistance
• Drug Therapy, Combination
• Fenbendazole (administration & dosage, therapeutic use)
• Helminthiasis (drug therapy)
• Helminthiasis, Animal
• Sheep
• Sheep Diseases (drug therapy)