Actions of a new vasopressin analogue (1-deamino-6-carba-[8-arginine]-vasopressin) on regional blood flow in pregnant guinea pigs.

Abstract

Regional blood flow responses to 1-deamino-6-carba-(8-arginine)-vasopressin (dCAVP) were investigated in pregnant guinea pigs by the radioactive microsphere technique. Intravenous injection of 0.1 microgram/kg body weight caused a moderate rise in mean arterial blood pressure from 6.8 to 7.9 kPa, a significant reduction in tissue perfusion of the stomach, mammary gland, urinary bladder and vagina, and a significant increase in renal and cerebral blood flow. In a small number of animals given 1.0 microgram/kg of dCAVP, which evoked a strong pressor response, it was also possible to demonstrate a reduction in cutaneous and pancreatic blood flow and an augmentation of adrenal blood flow. Uterine and maternal placental blood flow did not alter significantly following administration of this vasopressin analogue.

• Authors: P O Sjöquist, L Mårtensson, L Bjellin, A M Carter
• Journal: Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 43 Issue 3 Pg. 190-5 (Sep 1978) ISSN: 0001-6683 [Print] Denmark
• PMID: 707132 (Publication Type: Journal Article)

Chemical References

• Arginine Vasopressin

Topics

• Animals
• Arginine Vasopressin (administration & dosage, analogs & derivatives, pharmacology)
• Blood Pressure (drug effects)
• Female
• Guinea Pigs
• Heart Rate (drug effects)
• Injections, Intravenous
• Microspheres
• Placenta (blood supply)
• Pregnancy
• Regional Blood Flow (drug effects)