[Therapy of acute diseases of the upper airway. Comparison of 2 antiseptic pharyngeal sprays in otorhinolaryngologic practice].

Abstract

100 out-patients with subacute or acute stages of pharyngitis, tonsillitis, pharyngotonsillitis or angina participated in a randomized 3 day trial on antiseptic mouth-sprays comparing one containing a combination of chlorhexidine, tramazoline and aluminiumtrilactate with one containing only hexetidine. At the beginning of therapy and 3 days afterwards the local symptoms rubor and tumefaction of the throat, dysphagia, fur, swelling and tenderness of the cervical superficial lymph nodes were classified according to a graded scale. Using the combination these symptoms were markedly improved in 34 patients, improved in 7; 8 showed no alteration and one patient showed a deterioration (n = 50). With the monosubstance 18 patients showed good improvement, 11 an improvement, 17 no change and 3 patients a deterioration (n = 49), one patient needed penicillin-treatment during the trial. Under treatment with the combination the symptoms rubor and tumefaction of the throat showed a significant better improvement. The possible role played by a vasodilator are discussed.

• Authors: W Klingbeil
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 100 Issue 4 Pg. 146-9 (Jan 28 1982) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Therapie akuter Erkrankungen der oberen Atemwege. Therapievergleich zweier antiseptischer Rachen-Sprays in der HNO-Praxis.
• PMID: 7068093 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Aerosols
• Anti-Infective Agents, Local
• Drug Combinations
• Imidazoles
• Lactates
• lurgyl
• Hexetidine
• Chlorhexidine

Topics

• Aerosols
• Anti-Infective Agents, Local (adverse effects)
• Chlorhexidine (adverse effects, analogs & derivatives, therapeutic use)
• Drug Combinations (adverse effects, therapeutic use)
• Drug Evaluation
• Hexetidine (therapeutic use)
• Humans
• Imidazoles (adverse effects, therapeutic use)
• Lactates (adverse effects, therapeutic use)
• Otorhinolaryngologic Diseases (drug therapy)
• Pharynx
• Respiratory Tract Infections (drug therapy)