[Synthesis of 2-methoxynaphthalene derivatives as potential anti-inflammatory agents].

Abstract

Compounds having 2-methoxynaphthalene as their parent nucleus were synthesized and evaluated for antiinflammatory effect according to the carrageenin paw edema method in rats. The synthetic routes for the preparation of isomeric 1,2- and 2,6-disubstituted derivatives are described. Replacement of the alpha-methylacetic moiety in naproxen by 4-hydroxybutyric acid side chain did not cause loss of activity.

• Authors: V Cavrini, P Roveri, R Gatti, C Ferruzzi, A M Panico, M S Pappalardo
• Journal: Il Farmaco; edizione scientifica (Farmaco Sci) Vol. 37 Issue 3 Pg. 171-8 (Mar 1982) ISSN: 0430-0920 [Print] Italy
• Vernacular Title: Sintesi di derivati della 2-metossinaftalina come potenziali antiinfiammatori.
• PMID: 7067812 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Naphthalenes
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis)
• Carrageenan
• Edema (drug therapy)
• Male
• Naphthalenes (chemical synthesis, pharmacology)
• Rats
• Rats, Inbred Strains