Abstract |
A foundry worker developed dyspnea and a restrictive breathing defect after being exposed to diphenylmethane diisocyanate (MD) at work. His symptoms and lung function impairment subsided a few weeks after he left work. Specific inhalation challenges with the offending agent induced general malaise together with a significant increase in body temperature and leukocyte count as well as a significant decrease in forced vital capacity and transfer factor. Total antibody activity to a MDI human serum albumin (MDI-HSA) conjugate was detected by ammonium sulfate precipitation. Specific IgG antibodies were demonstrated by the enzyme-linked immunoabsorbent (ELISA) technique. Thus, it was found that MDI exposure can cause hypersensitivity pneumonitis and induce the production of specific antibodies.
|
Authors | J L Malo, C R Zeiss |
Journal | The American review of respiratory disease
(Am Rev Respir Dis)
Vol. 125
Issue 1
Pg. 113-6
(Jan 1982)
ISSN: 0003-0805 [Print] United States |
PMID | 7065501
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Cyanates
- Isocyanates
- 4,4'-diphenylmethane diisocyanate
|
Topics |
- Adult
- Alveolitis, Extrinsic Allergic
(chemically induced, immunology)
- Cyanates
- Humans
- Isocyanates
- Male
- Occupational Diseases
(chemically induced, immunology)
- Respiratory Function Tests
|