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Occupational hypersensitivity pneumonitis after exposure to diphenylmethane diisocyanate.

Abstract
A foundry worker developed dyspnea and a restrictive breathing defect after being exposed to diphenylmethane diisocyanate (MD) at work. His symptoms and lung function impairment subsided a few weeks after he left work. Specific inhalation challenges with the offending agent induced general malaise together with a significant increase in body temperature and leukocyte count as well as a significant decrease in forced vital capacity and transfer factor. Total antibody activity to a MDI human serum albumin (MDI-HSA) conjugate was detected by ammonium sulfate precipitation. Specific IgG antibodies were demonstrated by the enzyme-linked immunoabsorbent (ELISA) technique. Thus, it was found that MDI exposure can cause hypersensitivity pneumonitis and induce the production of specific antibodies.
AuthorsJ L Malo, C R Zeiss
JournalThe American review of respiratory disease (Am Rev Respir Dis) Vol. 125 Issue 1 Pg. 113-6 (Jan 1982) ISSN: 0003-0805 [Print] United States
PMID7065501 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Cyanates
  • Isocyanates
  • 4,4'-diphenylmethane diisocyanate
Topics
  • Adult
  • Alveolitis, Extrinsic Allergic (chemically induced, immunology)
  • Cyanates
  • Humans
  • Isocyanates
  • Male
  • Occupational Diseases (chemically induced, immunology)
  • Respiratory Function Tests

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