Renal and Auditory toxic effects of amikacin in children with cancer.

Abstract

Amikacin sulfate was given to 21 febrile children with neutropenia and cancer for 9 +/- 3 days. Peak serum amikacin levels ranged between 13 and 32 microgram/mL, and trough levels were consistently less than 2 microgram/mL. Renal toxic effects were detected in two children (9.5%) and were extremely mild. Two additional children (16.5%) experienced mild, transient, unilateral, high-frequency hearing losses. The lack of serious renal and auditory impairment suggests that children are at less risk than adults from aminoglycoside therapy.

• Authors: H Faden, G Deshpande, M Grossi
• Journal: American journal of diseases of children (1960) (Am J Dis Child) Vol. 136 Issue 3 Pg. 223-5 (Mar 1982) ISSN: 0002-922X [Print] United States
• PMID: 7064947 (Publication Type: Journal Article)

Chemical References

• Kanamycin
• Amikacin

Topics

• Adolescent
• Amikacin (adverse effects)
• Bacterial Infections (complications, drug therapy)
• Child
• Child, Preschool
• Hearing Loss (chemically induced)
• Hearing Loss, High-Frequency (chemically induced)
• Humans
• Infant
• Kanamycin (analogs & derivatives)
• Kidney Diseases (chemically induced)
• Neoplasms (complications)