Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam(p-(bis(2-chloroethyl)amino)-phenyl) acetate(NSC 290205) in murine solid tumors.

Abstract

The modified steroidal alkylating agent, 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam[p-[bis(2-chloroethyl)amino]-phenyl]acetate showed excellent activity in treatment of there murine solid tumors. Colon 26-bearing CD2F1 mice lived twice as long as controls with tumor free survivors at the end of the 70-day observation period. CD8F1 mammary tumor growth was suppressed greater than 90% compared to controls. B16 melanoma-bearing B6D2F1 mice lived 50% longer than controls. This agent had previously been shown to be active in treatment of the Theagenion-Bahner angiosarcoma, the T8 Guerin tumor, L1210 leukemia and P388 leukemia.

• Authors: P Catsoulacos, G L Wampler
• Journal: Oncology (Oncology) Vol. 39 Issue 2 Pg. 109-112 ( 1982) ISSN: 0030-2414 [Print] Switzerland
• PMID: 7063163 (Publication Type: Journal Article)

Chemical References

• Azasteroids
• Nitrogen Mustard Compounds
• NSC 290205

Topics

• Animals
• Azasteroids
• Carcinoma (drug therapy)
• Colonic Neoplasms (drug therapy, mortality)
• Female
• Lung Neoplasms (drug therapy, mortality)
• Male
• Mammary Neoplasms, Experimental (drug therapy)
• Melanoma (drug therapy, mortality)
• Mice
• Neoplasms, Experimental (drug therapy)
• Nitrogen Mustard Compounds (administration & dosage, therapeutic use)