Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928).

Abstract

Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.

• Authors: G P Wheeler, B J Bowdon, J A Werline, D J Adamson, C G Temple Jr
• Journal: Cancer research (Cancer Res) Vol. 42 Issue 3 Pg. 791-8 (Mar 1982) ISSN: 0008-5472 [Print] United States
• PMID: 7059977 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Pyrazines
• NSC 181928
• DNA
• Methotrexate

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Division (drug effects)
• Cell Line
• Cell Survival (drug effects)
• DNA (biosynthesis)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Methotrexate (pharmacology)
• Mice
• Mice, Inbred BALB C
• Mitosis (drug effects)
• Neoplasm Transplantation
• Neoplasms, Experimental (pathology)
• Pyrazines (pharmacology)