Abstract |
The first 36 patients with coronary arterial spasm treated with diltiazem and followed up at the Stanford University Coronary Artery Spasm Clinic for 6 months or longer are described. There were 13 men and 23 women with a mean age of 50.2 years; the mean duration of angina was 36.1 months. All patients had angina at rest with a good or fail response to sublingual nitroglycerin. During a mean of 17.5 months of diltiazem therapy, the frequency of angina was reduced from a mean of 21.5 to 1.3 attacks/week. This 94 percent reduction in pain frequency occurred when either 240 or 360 mg of diltiazem was administered daily. Sixteen patients required the addition of isosorbide dinitrate to achieve a painfree state. Pain breakthrough occurred a mean of 1.7 times during the 17.5 month follow-up period but tended to be of short duration. Six patients had trace to 1+ pedal edema and no other adverse effects occurred. It is concluded that diltiazem is highly effective and well tolerated for the long-term prophylaxis and treatment of angina in patients with coronary spasm.
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Authors | J S Schroeder, I H Lamb, R Ginsburg, M R Bristow, J Hung |
Journal | The American journal of cardiology
(Am J Cardiol)
Vol. 49
Issue 3
Pg. 533-7
(Feb 18 1982)
ISSN: 0002-9149 [Print] United States |
PMID | 7058764
(Publication Type: Journal Article)
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Chemical References |
- Benzazepines
- Diltiazem
- Isosorbide Dinitrate
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Topics |
- Adult
- Aged
- Angina Pectoris
(drug therapy)
- Angina Pectoris, Variant
(drug therapy)
- Benzazepines
(therapeutic use)
- Coronary Vasospasm
(drug therapy)
- Diltiazem
(therapeutic use)
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Female
- Humans
- Isosorbide Dinitrate
(therapeutic use)
- Male
- Middle Aged
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