Abstract |
Chemical carcinogens from several diverse chemical classes i.e.; aromatic amines, polycyclic hydrocarbons, nitrosamines, hormonal derivatives, metals and direct alkylating agents cause a 6.2-60.5-fold increase in the frequency of murine sarcoma virus (MSV)-induced transformation in a normal rat kidney (NRK) cell system. Exogenous metabolic activation with a rat liver S-9 homogenate is required for expression of this activity by procarcinogens. Non-carcinogenic analogs of these compounds fail to cause significant increases in the transformation frequency either with or without prior metabolic activation. Iododeoxyuridine, a mutagen also does not cause enhancement of transformation. This system may serve as the basis for a rapid and quantifiable means of identifying chemical carcinogens while introducing a new model for the understanding of the interactions between oncornaviruses and chemical carcinogens.
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Authors | W W Wilson, N Khoobyarian |
Journal | Chemico-biological interactions
(Chem Biol Interact)
Vol. 38
Issue 2
Pg. 253-9
(Jan 1982)
ISSN: 0009-2797 [Print] Ireland |
PMID | 7055852
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Carcinogens
(pharmacology)
- Cell Line
- Cell Transformation, Viral
(drug effects)
- Kidney
(drug effects, metabolism)
- Mice
- Moloney murine leukemia virus
- Rats
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