Serum level monitoring of thiothixene in schizophrenia: acute single-dose levels at fixed doses.

Abstract

After establishing a strong correlation between steady-state thiothixene levels and levels drawn 2.5 hours after a 20-mg test dose, the authors examined the correlation between clinical improvement and serum levels drawn 2.5 hours after a single 20-mg test dose of thiothixene. For 30 male schizophrenic inpatients, improvement on the Brief Psychiatric Rating Scale was significantly correlated with the single test-dose levels. Serum levels were also positively correlated with age, which may explain the tendency of elderly patients to require lower neuroleptic doses and to exhibit a higher incidence of side effects. The results suggest that acute single-dose levels may be useful in predicting clinical response to thiothixene.

• Authors: J A Yesavage, J Becker, P D Werner, M J Mills, C A Holman, R Cohn
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 139 Issue 2 Pg. 174-8 (Feb 1982) ISSN: 0002-953X [Print] United States
• PMID: 7055286 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Thiothixene

Topics

• Administration, Oral
• Adult
• Dose-Response Relationship, Drug
• Humans
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Psychotic Disorders (blood)
• Schizophrenia (blood, drug therapy)
• Schizophrenia, Catatonic (blood)
• Schizophrenia, Paranoid (blood)
• Thiothixene (blood, therapeutic use)