Normal cortical bone mass in patients after long term coumadin therapy.

Abstract

Clinical delineation of the warfarin embryopathy and the recent discovery of osteocalcin (a vitamin K-dependent bone protein) suggest that coumadin therapy could adversely affect the skeleton. Using bone densitometry and metacarpal cortical width measurement, we found normal cortical bone mass in 17 adults receiving long term coumadin therapy.

• Authors: L D Piro, M P Whyte, W A Murphy, S J Birge
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 54 Issue 2 Pg. 470-3 (Feb 1982) ISSN: 0021-972X [Print] United States
• PMID: 7054229 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vitamin K
• Warfarin

Topics

• Adult
• Aged
• Bone and Bones (anatomy & histology, drug effects)
• Densitometry
• Female
• Humans
• Male
• Metacarpus (anatomy & histology)
• Middle Aged
• Vitamin K (antagonists & inhibitors)
• Warfarin (pharmacology, therapeutic use)