Abstract |
A patient with primary thrombocythemia, who was heterozygous for glucose-6-phosphate dehydrogenase deficiency (GdB/GdMed), was investigated to test for the clonal origin of this myeloproliferative disorder. In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes.
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Authors | G F Gaetani, A M Ferraris, S Galiano, P Giuntini, L Canepa, M d'Urso |
Journal | Blood
(Blood)
Vol. 59
Issue 1
Pg. 76-9
(Jan 1982)
ISSN: 0006-4971 [Print] United States |
PMID | 7053766
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucosephosphates
- 2-deoxyglucose-6-phosphate
- Glucose-6-Phosphate
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Topics |
- Aged
- Blood Platelets
(metabolism)
- Erythrocytes
(metabolism)
- Female
- Glucose-6-Phosphate
(analogs & derivatives)
- Glucosephosphate Dehydrogenase Deficiency
(blood)
- Glucosephosphates
(metabolism)
- Granulocytes
(metabolism)
- Hematopoietic Stem Cells
(metabolism)
- Heterozygote
- Humans
- Mosaicism
- Thrombocytosis
(genetics, metabolism, pathology)
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