Sulindac-induced aseptic meningitis.

Abstract

A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 degrees C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin.

• Authors: Z K Ballas, S T Donta
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 142 Issue 1 Pg. 165-6 (Jan 1982) ISSN: 0003-9926 [Print] United States
• PMID: 7053720 (Publication Type: Case Reports, Journal Article)

Chemical References

• Indenes
• Sulindac

Topics

• Adult
• Drug Hypersensitivity (etiology)
• Female
• Humans
• Indenes (adverse effects)
• Lupus Erythematosus, Systemic (drug therapy)
• Meningitis (chemically induced)
• Meningitis, Aseptic (chemically induced)
• Sulindac (adverse effects, therapeutic use)