Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.

Abstract

The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system. The effect was then compared to that elicited by theophylline or levamisole, which both demonstrated thymosin-like action in vitro. The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V. Theophylline and levamisole demonstrated no antitumor effect.

• Authors: D Cupissol, A Rey, A L Goldstein, B Serrou
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 69 Issue 1 Pg. 27-31 (Jul 1982) ISSN: 0027-8874 [Print] United States
• PMID: 7047833 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Thymus Hormones
• Levamisole
• Methylcholanthrene
• Thymosin
• Theophylline

Topics

• Animals
• Bone Marrow Transplantation
• Cell Division (drug effects)
• Levamisole (pharmacology)
• Male
• Methylcholanthrene (pharmacology)
• Mice
• Mice, Inbred C57BL
• Neoplasm Transplantation
• Neoplasms (metabolism)
• Theophylline (pharmacology)
• Thymosin (pharmacology)
• Thymus Hormones (pharmacology)
• Time Factors