[UDPG pyrophosphorylase and phosphoglucomutase activity in the liver of rats with alloxan diabetes].

Abstract

The UDPH-pyrophosphatase and phosphomurase activity was determined in the liver homogenates of rats with manifest alloxan diabetes. In comparison with control animals, there was a statistically significant reduction of UDPH-pyrophosphorylase and phosphoglucomutase activity (by 29 and 33%, respectively) in diabetic rats. Decreased activity of the mentioned enzymes in the liver of rats with alloxan diabetes pointed to their participation in reduction of glycogen synthesis in the liver occurring in this disease.

• Authors: S A Shestakova, I M Sokoloverova
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1978 Sep-Oct Vol. 24 Issue 5 Pg. 71-3 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' UDFG-prifosforilazy i fosfogliukomutazy v pecheni krys pri alloksanovom diabete.
• PMID: 704561 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Liver Glycogen
• Nucleotidyltransferases
• UTP-Glucose-1-Phosphate Uridylyltransferase
• Phosphoglucomutase

Topics

• Animals
• Diabetes Mellitus, Experimental (enzymology)
• Enzyme Activation
• In Vitro Techniques
• Liver (enzymology)
• Liver Glycogen (metabolism)
• Nucleotidyltransferases (metabolism)
• Phosphoglucomutase (metabolism)
• Rats
• Time Factors
• UTP-Glucose-1-Phosphate Uridylyltransferase (metabolism)