A double-blind comparison of the effects of haloperidol and cis(Z)-clopenthixol in senile dementia.

Abstract

The therapeutic effects in senile dementia of haloperidol and cis(Z)-clopenthixol were compared in a double-blind, double-dummy clinical 8-week study in 47 demented patients after wash-out periods of 3 weeks or less. Forty patients, most of whom received 0.5 mg haloperidol or 5 mg cis(Z)-clopenthixol, completed the study in which assessments with the geriatric rating scales of Gottfries-Cronholm and Crichton in addition to CGI were done at weeks--3, 0, 1, 2, 4, and 8. With the Gottfries-Cronholm Scale few significant changes from week 0 were seen in the two groups of patients. Significant deteriorations at weeks 1 and 8 in the haloperidol group were, however, registered. The only significant difference between the two groups of patients regarded motor activity which was most positively influenced by cis(Z)-clopenthixol. Accordingly, most results suggesting a difference between the two test drugs were in the favour of cis(Z)-clopenthixol. With the Crichton and the CGi scales changes in the over-all impression of the patients were very few. Side effects were mild and transient.

• Authors: K G Götestam, S Ljunghall, B Olsson
• Journal: Acta psychiatrica Scandinavica. Supplementum (Acta Psychiatr Scand Suppl) Vol. 294 Pg. 46-53 ( 1981) ISSN: 0065-1591 [Print] Denmark
• PMID: 7041519 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Thioxanthenes
• Clopenthixol
• Haloperidol

Topics

• Aged
• Clinical Trials as Topic
• Clopenthixol (therapeutic use)
• Dementia (drug therapy)
• Double-Blind Method
• Female
• Haloperidol (therapeutic use)
• Humans
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Stereoisomerism
• Thioxanthenes (therapeutic use)