Abstract |
Acute and chronic studies were performed in the canine model to evaluate a new topical hemostatic agent in terms of initial hemostatic capability and tissue/material interaction during the healing process. IP760, a porous amylose succinate material, was applied to large splenic surface wounds in six acute and twelve chronic animals. Microfibrillar collagen ( Avitene) was used in twelve chronic animals for comparison. While the hemostatic capabilities of the two agents were comparable, marked differences were noted in the healing response. In the IP760-treated wound sites the acute inflammatory response, granulation tissue infiltration with fibrosis and healing occurred earlier and in a more homogeneous manner than in the Avitene-treated wound sites. Healing of the IP760-treated wounds occurred concomitantly with the development of granulation tissue and fibrosis and the rapid resorption of the IP760.
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Authors | D L Jeffery, D P Dressler, J M Anderson, M J Gallagher |
Journal | Journal of biomedical materials research
(J Biomed Mater Res)
Vol. 16
Issue 1
Pg. 51-61
(Jan 1982)
ISSN: 0021-9304 [Print] United States |
PMID | 7035459
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biocompatible Materials
- Hemostatics
- Polymers
- Succinates
- sodium amylose succinate
- Amylose
- Collagen
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Topics |
- Administration, Topical
- Amylose
(pharmacology)
- Animals
- Biocompatible Materials
- Collagen
(pharmacology)
- Dogs
- Hemostasis
- Hemostatic Techniques
- Hemostatics
(administration & dosage, pharmacology)
- Microscopy, Electron
- Polymers
(pharmacology)
- Spleen
(drug effects, injuries, pathology)
- Succinates
(pharmacology)
- Time Factors
- Wound Healing
(drug effects)
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