The effects of indomethacin in treated hypertensive patients.

Abstract

1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P less than 0.001)--average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P less than 0.01), plasma renin activity was reduced by 43% (P = 0.102) and plasma urea concentration was increased by 17% (P less than 0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.

• Authors: L M Wing, A J Bune, J P Chalmers, J R Graham, M J West
• Journal: Clinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) 1981 Sep-Oct Vol. 8 Issue 5 Pg. 537-41 ISSN: 0305-1870 [Print] Australia
• PMID: 7035040 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Antihypertensive Agents
• Aldosterone
• Renin
• Indomethacin

Topics

• Aged
• Aldosterone (blood)
• Antihypertensive Agents (therapeutic use)
• Blood Pressure (drug effects)
• Female
• Humans
• Hypertension (drug therapy)
• Indomethacin (therapeutic use)
• Male
• Middle Aged
• Renin (blood)