| Abstract | 1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P less than 0.001)--average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P less than 0.01), plasma renin activity was reduced by 43% (P = 0.102) and plasma urea concentration was increased by 17% (P less than 0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens. |
| Authors | L M Wing, A J Bune, J P Chalmers, J R Graham, M J West |
| Journal | Clinical and experimental pharmacology & physiology
(Clin Exp Pharmacol Physiol)
1981 Sep-Oct
Vol. 8
Issue 5
Pg. 537-41
ISSN: 0305-1870 ENGLAND |
| PMID | 7035040
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Antihypertensive Agents
- Aldosterone
- Indomethacin
- Renin
|
| Topics |
- Aged
- Aldosterone
(blood)
- Antihypertensive Agents
(therapeutic use)
- Blood Pressure
(drug effects)
- Female
- Humans
- Hypertension
(drug therapy)
- Indomethacin
(therapeutic use)
- Male
- Middle Aged
- Renin
(blood)
|
