| Abstract | Delayed-type hypersensitivity (DTH) to a soluble Mycobacterium leprae skin test antigen (SML) was successfully induced in healthy volunteers following immunization with 2 X 10(8) killed armadillo-derived M. leprae. No better sensitization was obtained by a mixture of live BCG and killed M. leprae. The relative specificity of the DTH reaction to SML has been demonstrated in this study, since little cross-reactivity was observed to PPD, after immunization with BCG ro M, leprae alone, or combined. Moreover, armadillo-derived M. leprae readily induced a specific hypersensitivity with the time course DTH response associated with protective immunity suggesting that this bacterial preparation may be a candidate for an effective anti-leprosy vaccine. |
| Authors | A H Smelt, R J Rees, F Y Liew |
| Journal | Clinical and experimental immunology
(Clin Exp Immunol)
Vol. 44
Issue 3
Pg. 501-6
(Jun 1981)
ISSN: 0009-9104 ENGLAND |
| PMID | 7035030
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
| Chemical References |
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| Topics |
- Adolescent
- Adult
- Antigens, Bacterial
(immunology)
- Female
- Humans
- Hypersensitivity, Delayed
- Immunization
- Mycobacterium bovis
(immunology)
- Mycobacterium leprae
(immunology)
- Skin Tests
- Time Factors
|
