HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protection against endometrial carcinoma by combination-product oral contraceptives.

Abstract
Seventy-nine patients with endometrial carcinoma were compared with 203 control subjects regarding their use of combination-product oral contraceptives (OCs). Overall, 6.3% of patients and 15.3% of control subjects had used these products. The risk of endometrial cancer for users of OCs was less than half the risk for nonusers. Five years or more of use reduced the risk to a third. Recent users were strongly protected, whereas discontinuation resulted in risks returning to those of nonusers. Furthermore, OCs with predominantly progestational effects of intermediate formulations produced greater protection than those with predominantly estrogens. This pattern of results is biologically consistent with a protective effect of combination-product OCs against endometrial carcinoma.
AuthorsB S Hulka, L E Chambless, D G Kaufman, W C Fowler Jr, B G Greenberg
JournalJAMA (JAMA) 1982 Jan 22-29 Vol. 247 Issue 4 Pg. 475-7 ISSN: 0098-7484 [Print] United States
PMID7033575 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Contraceptives, Oral
  • Contraceptives, Oral, Combined
  • Estrogens
  • Progestins
Topics
  • Adult
  • Age Factors
  • Clinical Trials as Topic
  • Contraceptives, Oral (adverse effects)
  • Contraceptives, Oral, Combined (adverse effects)
  • Estrogens (administration & dosage)
  • Female
  • Humans
  • Middle Aged
  • Myocardial Infarction (chemically induced)
  • Progestins (administration & dosage)
  • Risk
  • Thromboembolism (chemically induced)
  • Time Factors
  • Uterine Neoplasms (prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: