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Effects of alpha-methylnoradrenaline and alpha-methyldopamine in reserpine-induced ulcers in rats.

Abstract
alpha-Methyldopamine and alpha-methylnoradrenaline administered intraperitoneally afforded significant protection in reserpine-induced ulcers in rats. The optimal doses were 2 and 4 mg/kg. Lower and higher doses were less effective. alpha-Methyldopamine and alpha-methyl-noradrenaline probably act by reestablishing the normal adrenergic tone which is diminished in reserpine-induced ulcers.
AuthorsV Sandor, B Cuparencu
JournalPharmacology (Pharmacology) Vol. 23 Issue 2 Pg. 91-4 ( 1981) ISSN: 0031-7012 [Print] Switzerland
PMID7031706 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • alpha-methyldopamine
  • Reserpine
  • Deoxyepinephrine
  • Nordefrin
  • Dopamine
  • Norepinephrine
Topics
  • Animals
  • Anti-Ulcer Agents (pharmacology, therapeutic use)
  • Deoxyepinephrine (analogs & derivatives, pharmacology, therapeutic use)
  • Dopamine (analogs & derivatives)
  • Male
  • Nordefrin (pharmacology, therapeutic use)
  • Norepinephrine (analogs & derivatives)
  • Rats
  • Reserpine
  • Stomach Ulcer (chemically induced, drug therapy)

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