1. Gastric and pancreatic secretion as well as serum
gastrin an
insulin levels have been measured after
sham-feeding, real feeding or exogenous hormonal stimulation in conscious dogs receiving (pyro) Glu-
His-Gly, an appetite depressing
peptide (AP). 2.
Sham-feeding produced a marked increase in gastric acid and
pepsin outputs accompanied by an elevation of serum
gastrin and
insulin concentrations. AP infusion before and after
sham-feeding reduced the peak gastric secretion and suppressed
gastrin and
insulin responses to
sham-feeding. 3. Liver extract meal administered into the stomach resulted in an increase in gastric acid and serum
gastrin and
insulin levels. AP inhibited
acid response to liver extract without affecting serum hormonal levels.
Pentagastrin stimulation produced similar
acid secretion to that obtained with liver extract and AP infusion also inhibited this secretion. 4.
Secretin infusion or feeding a meat meal produced a similar rate of pancreatic
bicarbonate secretion in dogs with chronic
pancreatic fistula. AP infusion inhibited the
bicarbonate response to feeding or
secretin without affecting serum
gastrin or
insulin levels. 5. This study demonstrates that pyro-Glo-
His-Gly suppresses serum hormonal and gastric secretory response to cephalic stimulation and reduces
gastrin and pancreatic secretory responses to ordinary feeding or exogenous hormonal stimuli.