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A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice.

Abstract
Seventy-one patients with mild-to-moderate essential hypertension completed 14 weeks' treatment with a single daily dose of fixed combination of metoprolol tartrate 100 mg and chlorthalidone 25 mg (Logroton; Geigy). This represents 6958 patient-days of treatment. Mean blood pressures, both supine and standing, and pulse rates were reduced to and maintained at clinically acceptable levels during the trial period. No patient prematurely discontinued treatment because of insufficient therapeutic effect. Two patients discontinued the medication for drug-related reasons. Patient compliance was excellent and the preparation was well tolerated. The preparation was judged to be therapeutically effective in more than 80% of cases and is a valuable formulation for antihypertensive therapy.
AuthorsU Govind, B F Munro, L I Robertson
JournalSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 60 Issue 24 Pg. 921-4 (Dec 12 1981) ISSN: 0256-9574 [Print] South Africa
PMID7029740 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Drug Combinations
  • Propanolamines
  • Metoprolol
  • Chlorthalidone
  • Potassium
Topics
  • Adult
  • Blood Pressure (drug effects)
  • Body Weight (drug effects)
  • Chlorthalidone (administration & dosage)
  • Clinical Trials as Topic
  • Drug Combinations
  • Fundus Oculi (drug effects)
  • Humans
  • Hypertension (drug therapy)
  • Male
  • Metoprolol (administration & dosage, adverse effects)
  • Middle Aged
  • Potassium (blood)
  • Propanolamines (administration & dosage)
  • Pulse (drug effects)

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