Azatadine maleate (Zadine): evaluation in the management of allergic rhinitis.

Abstract

Azatadine maleate (Zadine), a new antihistamine, was evaluated for its efficacy in 20 patients with chronic allergic rhinitis. Eighty percent of patients had symptomatic relief with a twice daily dosage of 2 mg. Sedation was volunteered as a side effect by six of the patients and was admitted by two further patients after specific questioning. A choice reaction time test gave slowing of motor function in these sedated patients. Four of the previously sedated patients experienced good symptomatic control with minimal sedation when the azatadine dose was reduced to 1 mg twice daily; slowing of motor function was not observed at this, the normal recommended dose.

• Authors: J D Wilson, J L Hillas, S D Somerfield
• Journal: The New Zealand medical journal (N Z Med J) Vol. 94 Issue 689 Pg. 79-81 (Aug 12 1981) ISSN: 0028-8446 [Print] New Zealand
• PMID: 7024868 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyproheptadine
• azatadine

Topics

• Adolescent
• Adult
• Child
• Clinical Trials as Topic
• Cyproheptadine (adverse effects, analogs & derivatives, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Rhinitis, Allergic, Perennial (diagnosis, drug therapy)
• Rhinitis, Allergic, Seasonal (diagnosis, drug therapy)