A collaborative double-blind randomized trial was carried out involving 123 hospitalized patients with moderate or severe
pain following surgical interventions such as
episiotomy, vaginal uterus extirpation or
meniscectomy. The
analgesic effect of multiple oral doses of 4-(p-fluorophenyl)-1-isopropyl-7-2(1H)-quinazolinone (
fluproquazone) (100 mg) was compared with that of
paracetamol (500 mg). Self-assessments were made of
pain relief by the patients over a 3-day period. The results showed that
fluproquazone produced at least comparable relief to
paracetamol after the first dose and at the end of the overall treatment period. Furthermore, the
analgesic effect of
fluproquazone was significantly superior to
paracetamol after a 6-h period. Over-all tolerance to multiple doses was assessed as excellent or good by all the patients receiving
fluproquazone. The commonest side-effects in both treatment groups were gastrointestinal symptoms. However, the overall incidence of side-effects was lower in the
fluproquazone group and those that were reported were mostly mild as compared with the
paracetamol group.