A double-blind comparison of ibuprofen, ASA-codeine-caffeine compound and placebo in the treatment of dental surgery pain.

Abstract

A double-blind randomized clinical trial was conducted in eighty-seven patients with mild, moderate or severe dental surgery pain to evaluate the analgesic activity of a single dose of the following compounds: (i) ibuprofen 400 mg, (ii) ACC-30 (a compound containing ASA 375 mg; codeine phosphate 30 mg; caffeine citrate 30 mg), (iii) placebo. Ibuprofen was significantly better than ACC-30 and placebo on almost all pain intensity, degree of relief and duration of analgesia parameters. ACC-30 was not significantly different from placebo on any analgesic measurement. No serious side-effects were reported with any of the study medications.

• Authors: D J Squires, E L Masson
• Journal: The Journal of international medical research (J Int Med Res) Vol. 9 Issue 4 Pg. 257-60 ( 1981) ISSN: 0300-0605 [Print] England
• PMID: 7021262 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drug Combinations
• Placebos
• Caffeine
• Aspirin
• Codeine
• Ibuprofen

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aspirin (administration & dosage)
• Caffeine (administration & dosage)
• Clinical Trials as Topic
• Codeine (administration & dosage)
• Double-Blind Method
• Drug Combinations
• Female
• Humans
• Ibuprofen (therapeutic use)
• Male
• Pain, Postoperative (drug therapy)
• Placebos
• Random Allocation
• Surgery, Oral