[Mechanism of action of nonachlazine and ethmozine on the cardiac blood supply in acute myocardial ischemia].

Abstract

In anesthetized cats, intravenous administration of nonachlazin (1 and 6 mg/kg) and ethmozine (2 and 5 mg/kg) led, 5 minutes after ligation of the anterior descending branch of the left coronary artery, to the increased blood outflow from the coronary sinus and to a less marked elevation of myocardial oxygen consumption. The coronarodilatory effect of the drugs fell in the presence of a preliminary injection of the sympatholytic octadin (25 mg/kg intraperitoneally), atropine (0.5 mg/kg intravenously), alpha-adrenoblocker dihydroergotoxin (2 mg/kg intravenously), and beta-adrenoblocker obsidan (0.5 mg/kg intravenously). Nonachlazin and ethmozine decreased the pituitrin-induced (2 ED/kg intravenously) spasm of the coronary vessels of the affected heart.

• Authors: D B Pilipchuk
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1981 Jan-Feb Vol. 44 Issue 1 Pg. 63-7 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: K mekhanizmu deĭstviia nonakhlazina i étmozina na krovosnabzhenie serdtsa pri ostroĭ ishemii miokarda.
• PMID: 7021174 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Morpholines
• Phenothiazines
• Moricizine
• Nonachlazine

Topics

• Acute Disease
• Animals
• Cats
• Coronary Circulation
• Coronary Disease (drug therapy, metabolism, physiopathology)
• Female
• Male
• Moricizine
• Morpholines (therapeutic use)
• Myocardium (metabolism)
• Nonachlazine (therapeutic use)
• Oxygen Consumption
• Phenothiazines (therapeutic use)