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Short-term antibiotic prophylaxis and prostatectomy.

Abstract
Two hundred patients undergoing prostatic surgery at 2 hospitals were randomly allocated into 4 equal groups. The groups were a control, cephalexin, co-trimoxazole and carfecillin treated groups. The incidence of urinary tract infections and other complications of prostatic surgery were studied in each group after a short-term prophylactic regime of 3 doses of the antibiotic. The incidence of urinary infection was significantly improved from 28% in the control group to 8% and 16% in the co-trimoxazole and cephalexin groups respectively. Carfecillin was not effective in reducing urinary infection. However, all 3 antibiotics reduced the incidence of other infective sequelae.
AuthorsP J Shah, G Williams, M Chaudary
JournalBritish journal of urology (Br J Urol) Vol. 53 Issue 4 Pg. 339-43 (Aug 1981) ISSN: 0007-1331 [Print] England
PMID7020820 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Bacterial Agents
  • Drug Combinations
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Carfecillin
  • Trimethoprim
  • Sulfamethoxazole
  • Cephalexin
Topics
  • Anti-Bacterial Agents (therapeutic use)
  • Carfecillin (therapeutic use)
  • Cephalexin (therapeutic use)
  • Clinical Trials as Topic
  • Drug Combinations (therapeutic use)
  • Humans
  • Male
  • Postoperative Complications (prevention & control)
  • Premedication
  • Prostatectomy
  • Sulfamethoxazole (therapeutic use)
  • Trimethoprim (therapeutic use)
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Urinary Tract Infections (prevention & control)

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