Pyrazinamide deamidase activity in tuberculous disease.

Abstract

To investigate whether pyrazinamide deamidase activity is suppressed in tuberculosis, serial serum concentrations of pyrazinamide, following 40 mg of pyrazinamide per kg, were determined in 10 patients with sputum positive pulmonary tuberculosis and in 10 control subjects without disease. The concentrations and the half-lives of pyrazinamide were similar in the 2 groups, suggesting no suppression of the deamidase activity in tuberculous patients.

• Authors: P Gurumurthy, P V Krishnamurthy, G Garhupati Sarma
• Journal: The American review of respiratory disease (Am Rev Respir Dis) Vol. 124 Issue 1 Pg. 97 (Jul 1981) ISSN: 0003-0805 [Print] United States
• PMID: 7020509 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antitubercular Agents
• Pyrazinamide

Topics

• Antitubercular Agents (blood, therapeutic use)
• Clinical Trials as Topic
• Drug Evaluation
• Humans
• Pyrazinamide (blood, therapeutic use)
• Random Allocation
• Tuberculosis, Pulmonary (drug therapy, enzymology)