The evaluation of topical anti-inflammatory activity on rat ears subjected to thermal injury.

Abstract

Topical anti-inflammatory activity of steroidal and non-steroidal agents was assessed on inflammation produced by heat. A burn was produced on the ears of rats and the inflammation was quantitated gravimetrically. Steroidal anti-inflammatory agents were ranked in order of decreasing activity: triamcinolone acetonide, dexamethasone, prednisolone and hydrocortisone acetate. The nonsteroidal agents phenylbutazone and indomethacin were also effective in inhibiting the inflammation. Cholesterol, a steroid devoid of anti-inflammatory activity, was inactive in this test. Hydrocortisone acetate, in particular, appears to be less effective in inhibiting this type of inflammation than inflammation produced by croton oil.

• Authors: R L Bronaugh, R G Roller, R Cargill
• Journal: The Journal of investigative dermatology (J Invest Dermatol) Vol. 71 Issue 4 Pg. 263-5 (Oct 1978) ISSN: 0022-202X [Print] United States
• PMID: 701846 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Dexamethasone
• Prednisolone
• Triamcinolone Acetonide
• Phenylbutazone
• Hydrocortisone
• Indomethacin

Topics

• Administration, Topical
• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Burns (drug therapy)
• Dexamethasone (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Hydrocortisone
• Indomethacin (therapeutic use)
• Phenylbutazone (therapeutic use)
• Prednisolone
• Rats
• Triamcinolone Acetonide (therapeutic use)