Effect of 1 alpha hydroxylated vitamin D on steroid induced calcium malabsorption.

Abstract

As persistent bone loss is a major problem of chronic steroid therapy the effects of 3 weeks therapy with 1 alpha hydroxycholecalciferol were studied in 10 kidney transplant recipients on chronic steroid therapy. Treatment resulted in a significant increase in intestinal calcium absorption, paralleled by a significant decrease of serum iPTH, whereas neither plasma calcium nor urinary calcium excretion rose significantly, suggesting a positive calcium balance throughout the study. It is therefore suggested that administration of active vitamin D metabolites is an effective protection against one of the pathogenic mechanisms of steroid induced osteopenia.

• Authors: H Graf, H K Stummvoll, J Kovarik, H Bergmann, A Wolf
• Journal: Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association (Proc Eur Dial Transplant Assoc) Vol. 17 Pg. 736-40 ( 1980) ISSN: 0071-2736 [Print] England
• PMID: 7017705 (Publication Type: Journal Article)

Chemical References

• Hydroxycholecalciferols
• Immunosuppressive Agents
• Parathyroid Hormone
• Phosphates
• Creatinine
• Calcium
• alfacalcidol

Topics

• Calcium (metabolism)
• Calcium Metabolism Disorders (chemically induced, drug therapy)
• Creatinine (metabolism)
• Female
• Humans
• Hydroxycholecalciferols (pharmacology)
• Immunosuppressive Agents (adverse effects)
• Kidney Transplantation
• Male
• Parathyroid Hormone (blood)
• Phosphates (metabolism)
• Transplantation, Homologous