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Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase.

Abstract
Amino acid utilization was evaluated in seven children with acute lymphocytic leukemia treated with succinylated Acinetobacter glutaminase-asparaginase. All patients received food p.o. ad libitum and glucose-electrolyte solutions i.v.; four patients received an i.v. amino acid supplement (1.5 g/kg/day). Although all patients were in negative energy balance, there was a significant linear regression between nitrogen balance and nitrogen intake during Days 1 to 7 and Days 8 to 14 of the study. The slope of the regression line, reflecting exogenous nitrogen utilization, was not significantly different from that found in healthy young men ingesting adequate or subadequate energy intakes. The Y-intercept (-210 mg/kg/day) indicated an obligatory nitrogen loss that was much greater than normal. Most of the nitrogen loss was due to urinary excretion. Ammonia and urea accounted for 77 to 91% of the urine nitrogen. Urinary glutamate accounted for 4 to 10% of this loss. Urine protein excretion was abnormally high in each of the patients, ranging from 987 to 3440 mg/day. Urine excretion of N-acetyl-beta-glucosaminidase and beta 2-microglobulin was also abnormally high, despite normal blood urea nitrogen and serum creatinine, suggesting that these children had renal tubular dysfunction. The antileukemic effect of succinylated Acinetobacter glutaminase-asparaginase did not appear to be altered by amino acid supplementation. These data indicate that amino acid supplementation can improve nutritional status in patients treated with succinylated Acinetobacter glutaminase-asparaginase.
AuthorsC L Kien, J S Holcenberg
JournalCancer research (Cancer Res) Vol. 41 Issue 6 Pg. 2056-62 (Jun 1981) ISSN: 0008-5472 [Print] United States
PMID7016307 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Dietary Proteins
  • beta 2-Microglobulin
  • Acetylglucosaminidase
  • succinylated glutaminase-asparaginase
  • Asparaginase
  • Glutaminase
  • Nitrogen
Topics
  • Acetylglucosaminidase (urine)
  • Amino Acids (metabolism, pharmacology)
  • Asparaginase (adverse effects, therapeutic use)
  • Child
  • Dietary Proteins (metabolism)
  • Drug Administration Schedule
  • Glutaminase (adverse effects, therapeutic use)
  • Humans
  • Leukemia, Lymphoid (drug therapy, urine)
  • Nitrogen (metabolism)
  • Proteinuria (metabolism)
  • Regression Analysis
  • beta 2-Microglobulin (urine)

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