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L-5-Hydroxytryptophan-induced drinking in rats: possible mechanisms for induction.

Abstract
Administration of L-5-hydroxytryptophan (25 mg/kg body weight, SC) to female rats resulted in copious drinking. The dipsogenic response to administration of L-5-hydroxytryptophan (5-HTP) was blocked by propranolol (6 mg/kg body weight, IP), a beta-adrenergic antagonist, and captopril (35 mg/kg body weight, IP), an angiotensin converting enzyme inhibitor. In addition, clonidine (12.5 and 25 microgram/kg body weight, IP), a central alpha-adrenergic agonist known to inhibit renin release, attenuated drinking during 1, 2 and 3 hours after 5-HTP was administered. These results suggest that 5-HTP-induced drinking is mediated by way of the renin-angiotensin system. Haloperidol (150 microgram/kg body weight, IP), a dopaminergic antagonist, also attenuated the dipsogenic response to administration of 5-HTP. In addition, incremental reductions in 5-HTP-induced drinking with increasing doses of spiperone (37.5 to 150 microgram/kg body weight, IP), a more potent dopaminergic antagonist, were demonstrated. Thus, the dipsogenic response to administration of 5-HTP to rats is dependent on both the renin-angiotensin system and an intact dopaminergic pathway.
AuthorsR M Threatte, M J Fregly, T M Connor, D C Kikta
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 14 Issue 3 Pg. 385-91 (Mar 1981) ISSN: 0091-3057 [Print] United States
PMID7015366 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Spiperone
  • Captopril
  • Propranolol
  • 5-Hydroxytryptophan
  • Haloperidol
  • Clonidine
Topics
  • 5-Hydroxytryptophan (pharmacology)
  • Animals
  • Captopril (pharmacology)
  • Clonidine (pharmacology)
  • Drinking (drug effects)
  • Drug Interactions
  • Female
  • Haloperidol (pharmacology)
  • Propranolol (pharmacology)
  • Rats
  • Spiperone (pharmacology)
  • Stimulation, Chemical

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