Analgesic comparison of propiram fumarate with pentazocine, codeine, and placebo in postsurgical pain.

Abstract

The safety and effectiveness of a single oral dose of 50 mg propiram fumarate as an analgesic was compared in a double-blind clinical trial trial against single doses of standard reference analgesics (50 mg pentazocine hydrochloride or 60 mg codeine sulfate) or placebo. Subjects were adult patients experiencing severe postsurgical pain. Mean pain scores and SPID scores showed all three active drugs to be favored (P less than 0.05) over placebo in patients with severe initial pain. The most common side effects seen were drowsiness, nausea, and dizziness. These were not severe enough to require treatment. Propiram fumarate (50 mg) was shown to be an effective and safe analgesic in the treatment of severe postsurgical pain.

• Authors: J S Finch
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) 1980 Nov-Dec Vol. 20 Issue 11 Pg. 689-92 ISSN: 0091-2700 [Print] England
• PMID: 7014656 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Propionates
• Pyridines
• Pentazocine
• Codeine
• propiram

Topics

• Adolescent
• Adult
• Aged
• Analgesics (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Codeine (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Pain, Postoperative (drug therapy)
• Pentazocine (therapeutic use)
• Propionates (therapeutic use)
• Pyridines (therapeutic use)