Cell-mediated and humoral immune responses to chlamydial antigens in guinea pigs infected ocularly with the agent of guinea pig inclusion conjunctivitis.

Abstract

Cell-mediated immune response and humoral response to chlamydial antigens were investigated in guinea pigs infected with the agent of guinea pig inclusion conjunctivitis (GPIC). Pronounced cell-mediated immune response to the homologous antigen, as well as to two other chlamydial antigens, 6BC (Chlamydia psittaci) and LB-1 (C. trachomatis), occurred in all infected animals. Cell-mediated immune response to GPIC, and to a lesser extent to 6BC and LB-1 as well, was enhanced with time after infection even without the re-inoculation of the infectious agent. Extensive cross-reactions among the three chlamydial antigens during the cell-mediated immune response appeared to be due to shared species-specific and group-reactive antigens. Serum antibody response was pronounced and uniform to GPIC; it was less marked to 6BC and LB-1, with fewer cross-reactions than seen in tests for cell-mediated immunity.

• Authors: G Senyk, R Kerlan, D P Stites, D J Schanzlin, H B Ostler, L Hanna, H Keshishyan, E Jawetz
• Journal: Infection and immunity (Infect Immun) Vol. 32 Issue 1 Pg. 304-10 (Apr 1981) ISSN: 0019-9567 [Print] United States
• PMID: 7012031 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Macrophage Migration-Inhibitory Factors
• Tuberculin
• Freund's Adjuvant

Topics

• Animals
• Antibodies, Bacterial (biosynthesis)
• Antigens, Bacterial
• Chlamydia trachomatis (immunology)
• Conjunctivitis, Inclusion (diagnosis, immunology)
• Freund's Adjuvant (pharmacology)
• Guinea Pigs
• Immunity, Cellular
• Lymphocyte Activation
• Macrophage Migration-Inhibitory Factors (pharmacology)
• Skin Tests
• Tuberculin (immunology)